| Expression pattern: |
UP |
| Associated gene: |
SNAI1 |
| Associated microRNA: |
miR-153 |
| Biological function: |
circRBMS3 promotes GC cell proliferation and invasion in vitro and tumor growth in vivo; circRBMS3 knockdown reduces proliferation, invasion, and tumor growth. |
| Molecular mechanism: |
circRBMS3 acts as a miR-153 sponge and promotes SNAI1 expression via inhibiting miR-153, thereby regulating GC cell progression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRBMS3 expression is associated with advanced TNM stage, depth of invasion, lymph-node metastasis, and poor overall survival; circRBMS3 may serve as a novel promising biomarker and potential therapeutic target for GC treatment. |
| Description: |
circRBMS3/hsa_circ_0064644 is upregulated in gastric cancer tissues and cell lines and is associated with advanced disease features and poor overall survival. Functionally, circRBMS3 promotes gastric cancer cell proliferation, invasion, and xenograft tumor growth. Mechanistically, it acts through the miR-153/SNAI1 axis, increasing SNAI1 expression by inhibiting miR-153. |
| Confidence score: |
0.8057 |