| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Promotes prostate cancer cell proliferation; higher expression is correlated with less biochemical recurrence (protective coefficient in the prognostic model); detectable in plasma exosomes as a potential liquid biopsy biomarker. |
| Molecular mechanism: |
Potential interaction with miRNAs and proteins (database-based prediction); protein-coding potential reported for circ_17720, but mechanism not experimentally validated. |
| Biological pathway or process: |
proliferation (promotes); immune regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; Cohort Study; Survival Analysis; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Western Blot; Clinical Sample Validation |
| Clinical significance: |
Part of an eight-circRNA risk-score model predicting biochemical recurrence; high expression is correlated with less biochemical recurrence; detectable in exosomes of PCa patients’ plasma, suggesting potential as a liquid-biopsy marker. |
| Description: |
circ_17720 is part of an eight-circRNA model for predicting biochemical recurrence in prostate cancer, where higher expression is associated with less recurrence. Experimentally, it is downregulated in PCa cell lines, mainly localized in the cytoplasm, supports PCa cell proliferation, and is detectable in patient plasma exosomes; its downstream mechanism was not validated, though database-based miRNA/protein binding and coding potential were reported. |
| Confidence score: |
0.8209 |