| Expression pattern: |
UP |
| Associated gene: |
ATHL1, HTR6, KIAA1755, PLIN4, PRRT2, SNX29 |
| Associated microRNA: |
7 downregulated miRs |
| Biological function: |
Acupuncture and moxibustion may affect endometrial receptivity via regulation of circ-SFMBT2 expression; circ-SFMBT2 is an upregulated infertility-associated DEcircRNA and part of a circRNA-miR-mRNA network. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving circ-SFMBT2, downregulated miRs, and mRNAs including ATHL1, HTR6, KIAA1755, PLIN4, PRRT2, and SNX29. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potentially related to endometrial receptivity in infertile patients treated with acupuncture and moxibustion. |
| Description: |
circ-SFMBT2 was significantly upregulated in endometrial samples from infertile patients receiving acupuncture and moxibustion. It was incorporated into a predicted circRNA-miR-mRNA network, suggesting a possible ceRNA-related role in acupuncture/moxibustion-mediated modulation of endometrial receptivity. |
| Confidence score: |
0.4032 |