| Expression pattern: |
UP |
| Associated gene: |
EPSTI1 |
| Associated microRNA: |
- |
| Biological function: |
Associated with laboratory indicators and clinical manifestations in SLE; may be involved in SLE pathogenesis (in neutrophils). |
| Molecular mechanism: |
Not experimentally validated in this study; discussion suggests possible ceRNA-related regulation in other contexts. |
| Biological pathway or process: |
immune regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
Higher neutrophil hsa_circ_0000479 levels are associated with multiple laboratory indicators (NEUT, C3, anti-dsDNA, AnuA) and clinical manifestations (Raynaud’s phenomenon, alopecia, leucopenia) in SLE, suggesting potential clinical value. |
| Description: |
hsa_circ_0000479 (from host gene EPSTI1) is up-regulated in neutrophils from SLE patients versus healthy controls. Its higher neutrophil expression correlates with key laboratory parameters (e.g., lower NEUT and C3; higher anti-dsDNA and anti-nucleosome antibodies) and with Raynaud’s phenomenon, alopecia, and leucopenia, indicating potential involvement in SLE immune dysregulation and possible clinical value. |
| Confidence score: |
0.5129 |