| Expression pattern: |
UP |
| Associated gene: |
ENC1, Ago2 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
promotes proliferation, migration, invasion and metastasis; inhibits apoptosis |
| Molecular mechanism: |
circXRN2 acts as a miRNA sponge for miR-149-5p to upregulate ENC1 and induce EMT-related changes |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circXRN2 overexpression was linked to a poorer prognosis in patients |
| Description: |
circXRN2 is up-regulated in colorectal cancer tissues/cells and promotes CRC cell proliferation, migration, invasion and in vivo metastasis while inhibiting apoptosis. Mechanistically, it sponges miR-149-5p to upregulate ENC1 and induce EMT-related protein changes, forming a circXRN2/miR-149-5p/ENC1/EMT axis. High circXRN2 expression is associated with poorer prognosis in CRC patients. |
| Confidence score: |
0.8871 |