| Expression pattern: |
UP |
| Associated gene: |
STAT3, LDHA |
| Associated microRNA: |
miR-642b-3p |
| Biological function: |
promotes proliferation, migration, invasion and tumor growth in vivo; inhibits apoptosis; promotes aerobic glycolysis |
| Molecular mechanism: |
ceRNA mechanism: circ_MAPK9 sponges miR-642b-3p to relieve repression of STAT3 and LDHA, leading to STAT3 activation and increased LDHA expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation; Microarray |
| Clinical significance: |
High expression of circ_MAPK9 is associated with poor prognosis and shorter overall survival and disease-free survival in HCC patients; potential biomarker for poor prognosis and diagnosis |
| Description: |
circ_MAPK9 is up-regulated in HCC and acts as an oncogenic circRNA. It sponges miR-642b-3p to de-repress STAT3 and LDHA, enhancing STAT3 activation and LDHA-associated glycolysis, thereby promoting proliferation, migration/invasion, and tumor growth while inhibiting apoptosis; high circ_MAPK9 predicts poor survival. |
| Confidence score: |
0.8442 |