circRNA basic information
circBase ID: -
Name: hsa_circ_POLD1
Synonym: circPOLD1(3-2) / circPOLD1(3,2)
Host Gene: POLD1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0023113
MONDO name: familial colorectal cancer
Disease details: hereditary colorectal cancer / CRC predisposition
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with increased circRNA/mRNA ratio in CRC predisposition cohort; described as having oncogenic potential.
Molecular mechanism: Not demonstrated in this study; authors report imbalance likely reflects increased circRNA production or accumulation rather than decreased host-gene mRNA, suggesting independent regulation.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
S
Validation methods:

circRNA-seq; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

In blood, circRNA/mRNA imbalance in CRC patients was largely driven by circPOLD1(3,2), suggesting potential biomarker or functional contributor to cancer predisposition.
Description:

In peripheral blood from patients suspected of hereditary CRC, circPOLD1(3,2) is implicated as the main driver of an increased circRNA/mRNA ratio (relative to controls). The study suggests the imbalance likely reflects increased circRNA production/accumulation rather than reduced POLD1 mRNA, and highlights circPOLD1(3,2) as a candidate biomarker or contributor to CRC predisposition.
Confidence score:

0.5297
Other information
Title:

Simultaneous Study of Circular RNAs and Messenger RNAs in Colorectal Cancer: The Unbalanced Fate of a Couple?

Journal: Cancers
Published: 2026
PubMed ID: 41681969
Study type:

combined biological and clinical study
Data availability: The data presented in this study are available from the corresponding author upon request.
Code availability: available on request