| Expression pattern: |
UP |
| Associated gene: |
BMPR2 |
| Associated microRNA: |
- |
| Biological function: |
May be involved in the pathophysiology of endometriosis-associated infertility and abnormal follicular development through predicted circRNA-miRNA-mRNA regulation. |
| Molecular mechanism: |
Predicted ceRNA mechanism in a circRNA-miRNA-mRNA network; specific miRNA and mRNA partners were not named in the provided text for this circRNA. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic and therapeutic target for endometriosis-associated infertility. |
| Description: |
hsa_circ_0057799 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. It is spliced from BMPR2 and was included in the predicted circRNA-miRNA-mRNA ceRNA network, suggesting a potential role in abnormal follicular development. |
| Confidence score: |
0.5994 |