| Expression pattern: |
UP |
| Associated gene: |
MAD2L1 |
| Associated microRNA: |
miR-944 |
| Biological function: |
Promotes HCC cell proliferation, invasion, migration, glycolysis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0031242 acts as a ceRNA/sponges miR-944 to post-transcriptionally modulate MAD2L1 expression in HCC cells. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0031242 is up-regulated in HCC tissues and HCC cell lines. It promotes malignant HCC cell behaviors including proliferation, migration, invasion, glycolysis and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ_0031242 functions through a miR-944/MAD2L1 regulatory axis. |
| Confidence score: |
0.7662 |