| Expression pattern: |
UP |
| Associated gene: |
NOTCH2 |
| Associated microRNA: |
Micro-330-5p |
| Biological function: |
promotes proliferation and inhibits apoptosis in ox-LDL-induced HUVECs |
| Molecular mechanism: |
ceRNA-like regulation by targeting Micro-330-5p, thereby regulating NOTCH2 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); Notch (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircLZIC is highly expressed in human AS clinical serum samples. |
| Description: |
CircLZIC is up-regulated in atherosclerosis serum and in ox-LDL-treated HUVECs, and it promotes HUVEC proliferation/cell activity while inhibiting apoptosis. Mechanistically, circLZIC directly binds Micro-330-5p and modulates NOTCH2, forming a circLZIC/Micro-330-5p/NOTCH2 regulatory axis in AS. |
| Confidence score: |
0.7858 |