| Expression pattern: |
UP |
| Associated gene: |
Gli1 |
| Associated microRNA: |
microRNA-150, Has-miR-150-5p |
| Biological function: |
promotes colorectal cancer cell migration |
| Molecular mechanism: |
Circ-ZNF609 binds microRNA-150 and regulates Gli1 expression, thereby promoting colorectal cancer cell migration. |
| Biological pathway or process: |
migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
Circ-ZNF609 is up-regulated in colorectal cancer tissues and is predominantly cytoplasmic in HCT116 cells. It binds microRNA-150 and positively regulates Gli1 expression, thereby promoting colorectal cancer cell migration. |
| Confidence score: |
0.6676 |