circRNA basic information
circBase ID: -
Name: hsa_circ_LRP6
Synonym: circRNA LRP6 / hsa circRNA 101014
Host Gene: LRP6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005406
MONDO name: gestational diabetes
Disease details: gestational diabetes mellitus / GDM
Disease DO ID:
 11714
Disease MeSH ID:
 D016640
Disease NCIt ID:
 C34942
Disease ICD11 ID:
 1320503631
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Plasma circulating LRP6 is associated with increased risk of GDM and may aid in predicting GDM and pregnancy-related adverse events, especially foetal malformation and intrauterine death.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis
Clinical significance:

High plasma LRP6 expression effectively distinguished potential GDM patients and was associated with foetal malformation and intrauterine death.
Description:

This clinical cohort study found that plasma circRNA LRP6 is up-regulated in women who developed GDM. High LRP6 levels before pregnancy could predict future GDM risk and were associated with foetal malformation and intrauterine death, but no disease-specific molecular mechanism was experimentally tested.
Confidence score:

0.4758
Other information
Title:

Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.

Journal: Endocrinologia, diabetes y nutricion
Published: 2023
PubMed ID: 36925229
Study type:

clinical study
Data availability: -
Code availability: -