| Expression pattern: |
UP |
| Associated gene: |
CXCL6 |
| Associated microRNA: |
miR-515-5p |
| Biological function: |
Promotes GC cell growth, proliferation, migration and invasion; facilitates malignant biological behaviors of GC cells. |
| Molecular mechanism: |
circ_0006089 acts as a ceRNA/miRNA sponge by absorbing miR-515-5p, thereby up-regulating CXCL6 expression through the miR-515-5p/CXCL6 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; CCK8; BrdU; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
Circ_0006089 can probably act as one of the important biomarkers and therapeutic targets in GC treatment strategies. |
| Description: |
circ_0006089 is up-regulated in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes GC cell proliferation, migration and invasion by sponging miR-515-5p and increasing CXCL6 expression, suggesting potential value as a biomarker and therapeutic target. |
| Confidence score: |
0.7618 |