| Expression pattern: |
UP |
| Associated gene: |
HMGB1 |
| Associated microRNA: |
miR-363-3p |
| Biological function: |
circ_0002111 promotes PTC cell viability, proliferation, invasion, angiogenesis/tube formation and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0002111 functions as a ceRNA by sponging miR-363-3p to regulate HMGB1 expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0002111 inhibitor may be a promising drug candidate for PTC therapy. |
| Description: |
circ_0002111 is up-regulated in papillary thyroid carcinoma tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses PTC cell viability, proliferation, invasion, angiogenesis/tube formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0002111 sponges miR-363-3p to regulate HMGB1 expression, forming a circ_0002111/miR-363-3p/HMGB1 axis with potential therapeutic relevance. |
| Confidence score: |
0.7662 |