| Expression pattern: |
DN |
| Associated gene: |
beta-catenin, PI3K, AKT, CyclinD1, CDK6, Bax, Cleaved-caspase-3, Cleaved-caspase-9 |
| Associated microRNA: |
miR-183 |
| Biological function: |
circLMTK2 acts as a tumor suppressor in prostate cancer; its overexpression suppresses cell viability, proliferation, migration and invasion, and promotes apoptosis. |
| Molecular mechanism: |
circLMTK2 overexpression down-regulates miR-183 expression and inhibits PI3K/AKT and Wnt/beta-catenin pathways. |
| Biological pathway or process: |
PI3K/AKT (inhibits); Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; BrdU; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
circLMTK2 may offer a new strategy for PCa treatment. |
| Description: |
circLMTK2 is down-regulated in prostate cancer tissues and functions as a tumor suppressor. Overexpression of circLMTK2 inhibits proliferation, migration, invasion, metastasis-related behavior, PI3K/AKT signaling and Wnt/beta-catenin signaling while promoting apoptosis, largely through decreasing miR-183 expression. |
| Confidence score: |
0.5434 |