| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-646 |
| Biological function: |
circ_0000267 facilitates HCC cell growth, migration and invasion, attenuates apoptosis, and acts as an oncogenic circRNA associated with HCC initiation and progression. |
| Molecular mechanism: |
circ_0000267 promotes HCC carcinogenesis and progression by sponging miR-646; rescue assays indicate its oncogenic effects are partially attributed to suppression of miR-646. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Upregulation of circ_0000267 is associated with tumor size, TNM stages, clinical severity, poor prognosis, poorer 5-year overall survival, and is an independent prognostic indicator of overall survival in HCC patients. |
| Description: |
circ_0000267 is up-regulated in HCC tissues and cell lines and its high expression is associated with larger tumor size, advanced TNM stage, and poor overall survival. Functionally, it promotes HCC cell proliferation, migration, invasion and metastatic properties while inhibiting apoptosis. Mechanistically, circ_0000267 acts as an oncogenic circRNA partly by sponging miR-646. |
| Confidence score: |
0.7396 |