| Expression pattern: |
UP |
| Associated gene: |
AKT, phosphorylated AKT (Ser473), BCL2, BAX, BAK |
| Associated microRNA: |
- |
| Biological function: |
Promotes paclitaxel chemoresistance, increases cell viability/survival, inhibits apoptosis, and enhances invasion in breast cancer cells. |
| Molecular mechanism: |
circAMOTL1 binds phosphorylated AKT and increases total/phosphorylated AKT levels, altering downstream apoptosis-related gene/protein expression (upregulating BCL2 and downregulating BAX/BAK) to promote paclitaxel resistance. |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); invasion (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation) |
| Clinical significance: |
- |
| Description: |
circAMOTL1 increases paclitaxel resistance in triple-negative breast cancer cells by binding to phosphorylated AKT and elevating total/phosphorylated AKT levels. It shifts apoptosis regulators (BCL2 up, BAX/BAK down), thereby promoting survival and invasion under paclitaxel treatment. |
| Confidence score: |
0.6718 |