circRNA basic information
circBase ID: -
Name: mmu_circ_Foxo3
Synonym: circRNA FOXO3 (circFOXO3) / circFOXO3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005002
MONDO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease / COPD
Disease DO ID:
 3083
Disease MeSH ID:
 D029424
Disease NCIt ID:
 C3199
Disease ICD11 ID:
 133207228
Disease OMIM ID:
 606963
Species: Mouse
Species details: Mus musculus
Tissue specimen:

lungs / lung sections
Cell lines:

MLE-12 / MLE12
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F1
Associated microRNA: -
Biological function: promotes cigarette smoke/CSE-induced senescence of AT-II cells; inhibits autophagy in AT-II cells leading to lung injury
Molecular mechanism: circFOXO3 binds E2F1 and suppresses its nuclear translocation, thereby inhibiting autophagy and promoting AT-II cell senescence
Biological pathway or process:

autophagy (inhibits); apoptosis (other); senescence (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; IF (Immunofluorescence); In Vivo Animal Model
Clinical significance:

-
Description:

In mouse AT-II MLE-12 cells and a cigarette-smoke-exposed mouse model, circFOXO3 is induced by cigarette smoke/CSE and promotes AT-II cell senescence. Mechanistically, circFOXO3 binds the transcription factor E2F1, suppresses its nuclear translocation, inhibits autophagy, and thereby aggravates lung injury-related senescence.
Confidence score:

0.5925
Other information
Title:

Cigarette smoke-induced circFOXO3 upregulation enhances autophagy-regulated senescence of type II alveolar cells through interacting with E2F1.

Journal: Tobacco induced diseases
Published: 2026
PubMed ID: 41585093
Study type:

biological research
Data availability: The data supporting this research are available from the authors on reasonable request.
Code availability: -