circRNA basic information
circBase ID: hsa_circ_0120106
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissue specimen; adjacent non-neoplastic tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TGFB1I1
Associated microRNA: -
Biological function: unknown
Molecular mechanism: ceRNA network analysis suggested circRNA-miRNA-mRNA interactions (predicted)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

potential biomarker for diagnosis of LUAD (AUC=0.949)
Description:

hsa_circ_0120106 is significantly down-regulated in LUAD tissues and shows strong diagnostic potential by ROC analysis (AUC 0.949). The study constructs a predicted circRNA-miRNA-mRNA ceRNA network for LUAD, and notes prior literature that hsa_circ_0120106 can recruit TGFB1I1.
Confidence score:

0.5047
Other information
Title:

Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.

Journal: Thoracic cancer
Published: 2023
PubMed ID: 37137710
Study type:

combined biological and clinical study
Data availability: All the data obtained and/or analyzed during the current study are available from the corresponding authors on reasonable request.
Code availability: -