circRNA basic information
circBase ID: -
Name: hsa_circ_HNRNPH1
Synonym: circRNA-000425
Host Gene: HNRNPH1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HGC-27; BGC-823
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: YAP1, p21, BIM
Associated microRNA: miR-17, miR-106b
Biological function: Functions as a tumor suppressor; suppresses cancer cell growth induced by miR-17; rescues the inhibitory effects of miR-17 and miR-106b on p21 and BIM expression.
Molecular mechanism: YAP1 transcriptionally suppresses circRNA-000425 expression; circRNA-000425 acts as a sponge for miR-17 and miR-106b and reverses their inhibitory effects on p21 and BIM.
Biological pathway or process:

Hippo/YAP (other); proliferation (inhibits); cell cycle (inhibits); apoptosis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identifies circRNA-000425 as a YAP1-repressed circRNA in gastric cancer cell models. circRNA-000425 binds miR-17 and miR-106b, relieves their suppression of p21 and BIM, and inhibits miR-17-induced cancer cell growth, supporting a tumor-suppressive role within the Hippo-YAP1-associated regulatory context.
Confidence score:

0.717
Other information
Title:

YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106.

Journal: Biochemical and biophysical research communications
Published: 2018
PubMed ID: 30017188
Study type:

biological research
Data availability: Supplementary Table 1; Supplementary data related to this article can be found at https://doi.org/10.1016/j.bbrc.2018.06.163.
Code availability: -