| Expression pattern: |
DN |
| Associated gene: |
WNT7B, Ago2 |
| Associated microRNA: |
miR-619 |
| Biological function: |
circPTK2 promotes trophoblast cell proliferation, migration, invasion and glucose metabolism; circPTK2 knockdown inhibits HTR8/SVneo cell proliferation, invasion, glucose uptake and lactate production. |
| Molecular mechanism: |
circPTK2 acts as a ceRNA sponge for miR-619 and regulates WNT7B expression through the circPTK2/miR-619/WNT7B axis. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
circPTK2 has potential as a diagnostic biomarker and therapeutic target for EOPE. |
| Description: |
circPTK2 is down-regulated in placental tissues from PE/EOPE patients. Functionally, circPTK2 promotes trophoblast proliferation, migration, invasion and glucose metabolism, while its knockdown suppresses these processes. Mechanistically, circPTK2 acts as a miR-619 sponge to regulate WNT7B expression, supporting its potential as a biomarker and therapeutic target for EOPE. |
| Confidence score: |
0.725 |