| Expression pattern: |
DN |
| Associated gene: |
VASP, KRT17 |
| Associated microRNA: |
- |
| Biological function: |
inhibits CRC cell proliferation, migration, and invasion; suppresses tumor growth in vivo |
| Molecular mechanism: |
circXPO1-2 overexpression down-regulates positive regulators of AKT/ERK pathway (e.g., VASP, KRT17) and modulates apoptosis and oxidative phosphorylation programs. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); oxidative phosphorylation (promotes); cell cycle (inhibits); MAPK (inhibits); ERK (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
circXPO1-2 was significantly down-regulated in CRC tumor tissues compared with matched adjacent non-tumor tissues; lower expression in TNM late-stage. |
| Description: |
circXPO1-2 is significantly down-regulated in colorectal cancer tissues and is mainly localized in the cytoplasm. Its overexpression suppresses CRC cell proliferation, migration, invasion and xenograft tumor growth, potentially by down-regulating AKT/ERK-associated regulators (e.g., VASP, KRT17) and shifting gene programs toward apoptosis and oxidative phosphorylation. |
| Confidence score: |
0.7663 |