| Expression pattern: |
DN |
| Associated gene: |
CDK2 |
| Associated microRNA: |
hsa-miR-638 |
| Biological function: |
circNCOR1 promotes TNBC cell proliferation and colony formation, inhibits radiation-induced apoptosis, and reduces radiosensitivity during breast cancer radiotherapy. |
| Molecular mechanism: |
circNCOR1 functions as a ceRNA/miRNA sponge that binds hsa-miR-638 and positively regulates CDK2 expression, thereby reducing TNBC radiosensitivity. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); radioresistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; circRNA-seq; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis |
| Clinical significance: |
circNCOR1 may be a potential therapeutic target for TNBC treatment and radiotherapy efficacy. |
| Description: |
circNCOR1 is a human NCOR1-derived circRNA that is downregulated after irradiation in TNBC cell lines. Its overexpression promotes proliferation and colony formation, inhibits radiation-induced apoptosis, and decreases radiosensitivity by sponging hsa-miR-638 to increase CDK2 expression. In xenograft tumors, circNCOR1 overexpression partially reverses radiation-induced tumor structural loosening and apoptosis. |
| Confidence score: |
0.8279 |