| Expression pattern: |
UP |
| Associated gene: |
ITGB8 |
| Associated microRNA: |
miR-1229-3p |
| Biological function: |
Promotes glioma cell proliferation, cell cycle progression, migration, invasion, EMT, and in vivo tumor growth; knockdown inhibits these phenotypes and increases apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1229-3p to positively regulate ITGB8 expression. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0037655 is up-regulated in glioma tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-1229-3p to increase ITGB8 expression, thereby promoting proliferation, cell-cycle progression, migration/invasion, EMT, and in vivo tumor growth; circ_0037655 knockdown reverses these phenotypes. |
| Confidence score: |
0.6973 |