circRNA basic information
circBase ID: hsa_circ_0001944
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

brain metastatic breast cancer cell line 231-BR; parental nonspecific metastatic cell line MDA-MB-231
Cell lines:

231-BR; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-509, miR-509-3-5p, miR-509-5p
Biological function: may be involved in breast cancer brain metastasis; may act as a biomarker and therapeutic target
Molecular mechanism: ceRNA mechanism
Biological pathway or process:

metastasis (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
S
Validation methods:

RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RNA-seq; Clinical Sample Validation
Clinical significance:

may be used as biomarkers for diagnosis and prediction of BCBM; may also be therapeutic targets
Description:

hsa circ 0001944 is upregulated in breast cancer brain metastasis cells and was validated by RNA-seq, RT-qPCR, and agarose gel electrophoresis. The study suggests it may act as a miRNA sponge for miR-509 and potentially contribute to BCBM, with possible diagnostic and therapeutic relevance.
Confidence score:

0.5909
Other information
Title:

Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.

Journal: Epigenomics
Published: 2018
PubMed ID: 30810051
Study type:

biological research
Data availability: -
Code availability: -