| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-197-5p |
| Biological function: |
May play a role in human breast cancer; associated with histological type and lymph node metastasis; may serve as a potential tumor marker for breast cancer screening. |
| Molecular mechanism: |
hsa_circ_0006220 may regulate miR-197-5p, suggesting a possible miRNA sponge or ceRNA-related mechanism. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection |
| Clinical significance: |
Downregulated hsa_circ_0006220 was inversely correlated with histological type and lymph node metastasis; ROC AUC was 0.706; may be a potential biomarker or tumor marker for breast cancer screening. |
| Description: |
hsa_circ_0006220 is significantly downregulated in human breast cancer tissues and its lower expression is associated with histological type and lymph node metastasis. The study suggests that hsa_circ_0006220 may act through regulation of miR-197-5p and may serve as a potential biomarker for breast cancer screening. |
| Confidence score: |
0.5849 |