| Expression pattern: |
UP |
| Associated gene: |
SND1, ADAM9 |
| Associated microRNA: |
miR-126-3p |
| Biological function: |
promotes migration, invasion and metastasis of bladder cancer cells |
| Molecular mechanism: |
binds and stabilizes SND1 protein to enhance SND1-mediated endonucleolytic miRNA decay (miR-126-3p), leading to ADAM9 accumulation |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; FISH / smFISH; ISH (In Situ Hybridization); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
expression of hsa_circ_0001583 was significantly related with metastasis-free survival; potential biomarker for higher metastasis propensity |
| Description: |
hsa_circ_0001583 is up-regulated in bladder cancer tissues and promotes migration/invasion and lung metastasis. Mechanistically, it binds and stabilizes SND1, enhancing SND1-mediated miR-126-3p decay, which relieves repression of ADAM9 and drives a pro-metastatic phenotype. |
| Confidence score: |
0.8717 |