| Expression pattern: |
DN |
| Associated gene: |
RCAN1 |
| Associated microRNA: |
miR-572 |
| Biological function: |
Suppresses HCC progression by inhibiting cell proliferation, migration, invasion and tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
circADAMTS14 functions as a competing endogenous RNA sponge for miR-572, thereby upregulating RCAN1 expression and suppressing HCC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); apoptosis (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circADAMTS14 may serve as a prognostic and prediction marker, therapeutic biomarker, diagnostic marker, and valuable biomarker for precision medicine in HCC. |
| Description: |
circADAMTS14 is down-regulated in HCC tissues and cell lines. It suppresses HCC progression by acting as a competing endogenous RNA that sponges miR-572 and increases RCAN1 expression, thereby inhibiting proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. |
| Confidence score: |
0.7799 |