circRNA basic information
circBase ID: hsa_circ_0000826
Name: -
Synonym: cir-cRNA.1213 / circ_0000826
Host Gene: -
Genomic location(hg19): chr18:9182379-9221997:+
Genomic location(hg38): chr18:9182381-9221999:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues; tumor and nontumor tissues
Cell lines:

SW620; HCT116; HCT8; LOVO; Caco2; SW480; RKO; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May promote the proliferation and migration of CRC; associated with tumor size, TNM stage, and distant metastasis.
Molecular mechanism: Not specified; the study reports differential expression and clinicopathological association.
Biological pathway or process:

proliferation (promotes); migration (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Downregulation was correlated with tumor size, TNM stage, and distant metastasis; may have diagnostic value.
Description:

hsa_circ_0000826 was identified by RNA sequencing and validated by RT-qPCR as significantly downregulated in CRC tissues and most CRC cell lines. Its expression was associated with tumor size, TNM stage, lymph metastasis, and distant metastasis, suggesting potential diagnostic or clinicopathological relevance in CRC.
Confidence score:

0.4032
Other information
Title:

Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.

Journal: Journal of cellular biochemistry
Published: 2019
PubMed ID: 30320923
Study type:

combined biological and clinical study
Data availability: Supporting Information Data1
Code availability: -