| Expression pattern: |
DN |
| Associated gene: |
MYD88 |
| Associated microRNA: |
miR-6721-5p |
| Biological function: |
potential roles in the pathogenesis of tuberculosis and anti-TB defense of host cells |
| Molecular mechanism: |
ceRNA mechanism (circRNA-miRNA-mRNA network) predicted |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Sanger Sequencing; divergent primers PCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis |
| Clinical significance: |
potential diagnostic markers and therapeutic targets for mycobacterium infection |
| Description: |
circTNFRSF21 is down-regulated in M.tb-infected THP-1 macrophages and is mainly localized in the cytoplasm. The study predicts a ceRNA axis circTNFRSF21/miR-6721-5p/MYD88 that may be associated with M.tb infection. |
| Confidence score: |
0.5439 |