| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-518a-5p |
| Biological function: |
Downregulation of circ_0001320 attenuates the inhibitory effects of ropivacaine on NSCLC cell proliferation, migration, invasion and angiogenesis, and reduces ropivacaine-induced apoptosis; circ_0001320 acts as an anti-tumor factor in this context by inhibiting miR-518a-5p. |
| Molecular mechanism: |
circ_0001320 directly targets (sponges) miR-518a-5p as validated by CircInteractome prediction and dual-luciferase assay, thereby inhibiting miR-518a-5p expression and mediating ropivacaine's anti-NSCLC effects. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); angiogenesis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0001320 is down-regulated in NSCLC tissues and cell lines and is induced by ropivacaine. Functionally, circ_0001320 mediates ropivacaine's anti-tumor effects by targeting and suppressing miR-518a-5p, thereby inhibiting proliferation/migration/invasion/angiogenesis and promoting apoptosis in NSCLC cells. |
| Confidence score: |
0.6815 |