| Expression pattern: |
UP |
| Associated gene: |
CNNM3, MACC1 |
| Associated microRNA: |
miR-337-3p |
| Biological function: |
Promotes cervical cancer cell viability, proliferation, migration, and invasion, and inhibits apoptosis; associated with lymph node invasion, myometrial invasion, and unfavorable overall survival. |
| Molecular mechanism: |
hsa_circ_0001038 acts as a ceRNA by sponging miR-337-3p, thereby upregulating CNNM3 and MACC1 expression at the posttranscriptional level. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher hsa_circ_0001038 expression was related to positive lymph node invasion, myometrial invasion, and reduced overall survival; hsa_circ_0001038 is a potential prognostic biomarker for CC. |
| Description: |
hsa_circ_0001038 is up-regulated in cervical cancer tissues and cell lines and high expression predicts poorer overall survival. Functionally, it promotes cervical cancer cell growth, migration, and invasion while suppressing apoptosis. Mechanistically, it acts as a ceRNA for miR-337-3p to increase CNNM3 and MACC1 expression. |
| Confidence score: |
0.7113 |