| Expression pattern: |
UP |
| Associated gene: |
ANXA2 / Annexin A2 / Ago2 |
| Associated microRNA: |
miR-23b-3p |
| Biological function: |
promotes proliferation, migration/invasion, tumor growth, metastasis and EMT in ovarian cancer |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0013561 sponges miR-23b-3p to increase ANXA2, promoting EMT and metastasis |
| Biological pathway or process: |
EMT (promotes); metastasis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Sanger Sequencing; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0013561 expression is associated with metastasis formation and poor prognosis; may serve as an oncogenic biomarker for OC progression |
| Description: |
hsa_circ_0013561 is up-regulated in ovarian cancer tissues/cells (highest in metastatic tissues) and promotes proliferation, migration/invasion, tumor growth, metastasis and EMT. Mechanistically, it functions as a ceRNA by binding miR-23b-3p to increase ANXA2 expression, driving EMT and tumor progression. |
| Confidence score: |
0.7981 |