| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Hsa_circ_0000567 acts as a suppressor in CRC; decreased expression is associated with tumor growth and metastasis, and knockdown promotes CRC cell proliferation and migration in vitro. |
| Molecular mechanism: |
The molecular mechanism was not experimentally uncovered; the study suggests possible post-transcriptional regulation as a future direction. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased hsa_circ_0000567 expression is negatively correlated with tumor size, lymph metastasis, distal metastasis, and TNM stage; ROC analysis showed AUC = 0.8653, indicating diagnostic biomarker potential for CRC. |
| Description: |
Hsa_circ_0000567 is a SETD3-derived circular RNA that is significantly downregulated in colorectal cancer tissues and cell lines. Its reduced expression is associated with larger tumors, metastasis, and advanced TNM stage, while knockdown promotes CRC cell proliferation and migration, supporting a tumor-suppressive role. ROC analysis suggests hsa_circ_0000567 has potential diagnostic biomarker value for CRC. |
| Confidence score: |
0.7729 |