| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
circ_0032627 promotes proliferation and inhibits apoptosis of gastric cancer cells. |
| Molecular mechanism: |
circ_0032627 acts as a ceRNA/miRNA sponge for miR-502-5p and inhibits miR-502-5p expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
potential target in treating gastric cancer and understanding development and progression mechanisms |
| Description: |
circ_0032627 is up-regulated in human gastric cancer cell lines compared with a human gastric mucosal cell line. Functionally, circ_0032627 promotes gastric cancer cell proliferation and suppresses apoptosis. Mechanistically, it acts as a sponge of miR-502-5p, thereby contributing to gastric cancer development and progression. |
| Confidence score: |
0.5554 |