| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-181 |
| Biological function: |
hsa_circ_0007385 functions as an oncogenic circRNA in NSCLC; knockdown suppresses NSCLC cell proliferation, migration and invasion in vitro and inhibits tumor growth in vivo. |
| Molecular mechanism: |
hsa_circ_0007385 may act through a miRNA sponge-related regulatory pathway involving miR-181. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
providing a potential therapeutic target for NSCLC |
| Description: |
hsa_circ_0007385 is up-regulated in NSCLC tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses NSCLC cell proliferation, migration and invasion in vitro and reduces xenograft tumor growth in vivo. Mechanistically, the study suggests that hsa_circ_0007385 may function through a miR-181-related regulatory pathway. |
| Confidence score: |
0.7785 |