circRNA basic information
circBase ID: hsa_circ_0059730
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr20:30380537-30386355:+
Genomic location(hg38): chr20:31792734-31798552:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue samples; paired adjacent normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: ADSL, TRNP1, MAPRE1
Associated microRNA: miR-516a-5p, miR-378g, miR-515-5p
Biological function: unknown
Molecular mechanism: ceRNA axis prediction: hsa_circ_0059730 sponges miR-516a-5p to regulate ADSL; sponges miR-378g to regulate TRNP1; sponges miR-515-5p to regulate MAPRE1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Three of the five circRNA-miRNA-mRNA mechanistic axes correlating negatively with HCC prognosis involve hsa_circ_0059730 (hsa_circ_0059730/miR-516a-5p/ADSL; hsa_circ_0059730/miR-378g/TRNP1; hsa_circ_0059730/miR-515-5p/MAPRE1).
Description:

hsa_circ_0059730 was differentially expressed in HCC and validated by qRT-PCR in clinical tissues. The paper proposed three prognostically relevant ceRNA axes involving hsa_circ_0059730 (with miR-516a-5p/ADSL, miR-378g/TRNP1, and miR-515-5p/MAPRE1), derived from bioinformatic prediction and ceRNA network construction without direct interaction assays.
Confidence score:

0.4032
Other information
Title:

Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.

Journal: Scientific reports
Published: 2023
PubMed ID: 38086834
Study type:

combined biological and clinical study
Data availability: GSE242797
Code availability: -