| Expression pattern: |
DN |
| Associated gene: |
c-Myc, FNDC3B-267aa, Snail, Slug |
| Associated microRNA: |
- |
| Biological function: |
inhibits gastric cancer cell migration and metastasis (via translating FNDC3B-267aa) |
| Molecular mechanism: |
circ0003692 encodes FNDC3B-267aa; FNDC3B-267aa binds c-Myc and promotes proteasome-mediated degradation of c-Myc, suppressing the c-Myc-Snail/Slug axis |
| Biological pathway or process: |
migration (inhibits); metastasis (inhibits); EMT (inhibits); ubiquitination (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; Co-IP; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Circ0003692 is decreased in GC and associated with T, N, M grade; circ0003692 expression did not correlate with the overall survival of GC patients. |
| Description: |
circ0003692 (hsa_circ_0003692), derived from FNDC3B, is down-regulated in gastric cancer tissues and associates with advanced TNM grades. It acts mainly by encoding the peptide FNDC3B-267aa, which binds c-Myc and promotes its proteasomal degradation, thereby suppressing the c-Myc-Snail/Slug axis and reducing GC migration/metastasis. |
| Confidence score: |
0.8707 |