circRNA basic information
circBase ID: hsa_circ_0088251
Name: hsa_circ_PAPPA
Synonym: -
Host Gene: PAPPA
Genomic location(hg19): chr9:119109304-119130033:+
Genomic location(hg38): chr9:116347025-116367754:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tissue; breast tumor; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PAPPA
Associated microRNA: hsa-miR-326-3p
Biological function: unknown
Molecular mechanism: Predicted miRNA sponging (ceRNA) within an mRNA/circRNA/miRNA axis (PAPPA/hsa_circ_0088251/hsa-miR-326-3p).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Proposed as part of an early tumor initiation biomarker axis (PAPPA/hsa_circ_0088251/hsa-miR-326-3p) for breast cancer.
Description:

hsa_circ_0088251 is down-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-326-3p as part of the PAPPA/hsa_circ_0088251/hsa-miR-326-3p axis for early breast cancer initiation biomarker screening.
Confidence score:

0.348
Other information
Title:

CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.

Journal: International journal of molecular sciences
Published: 2024
PubMed ID: 39684767
Study type:

bioinformatics study
Data availability: GSE182471; GSE154255
Code availability: -