circRNA basic information
circBase ID: hsa_circ_0000729
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:90098243-90098338:+
Genomic location(hg38): chr16:90031835-90031930:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; paired adjacent normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-375
Biological function: Proposed to act as a miR-375 sponge in LUAD.
Molecular mechanism: Potential miRNA sponge (ceRNA-like) relationship with miR-375; downstream targets not specified for this circRNA.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Reported diagnostic accuracy as a biomarker for LUAD (ROC AUC=0.815).
Description:

hsa_circ_0000729 is up-regulated in LUAD clinical tissues by qRT-PCR and is suggested to sponge miR-375 (negative association). It shows diagnostic biomarker potential with ROC AUC ~0.815.
Confidence score:

0.459
Other information
Title:

hsa_circ_0000729, a potential prognostic biomarker in lung adenocarcinoma.

Journal: Thoracic cancer
Published: 2018
PubMed ID: 29932500
Study type:

combined biological and clinical study
Data availability: GSE101586
Code availability: -