| Expression pattern: |
UP |
| Associated gene: |
TXNDC5 mRNA, thioredoxin domain-containing protein 5 (TXNDC5), Argonaute2 (AGO2) |
| Associated microRNA: |
miR-218-5p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circRNA-104718 acts as a competing endogenous RNA that binds miR-218-5p, relieves miR-218-5p-mediated suppression of TXNDC5, and promotes HCC progression through the miR-218-5p/TXNDC5 pathway. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); circRIP; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRNA-104718 expression is associated with poor prognosis, low survival rates, vascular invasion, tumor metastasis, and may serve as a diagnostic and prognostic marker and therapeutic target for HCC. |
| Description: |
circRNA-104718 is up-regulated in HCC tissues and high expression is associated with poor survival, vascular invasion and metastasis. Functionally, it promotes HCC proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-218-5p, thereby relieving miR-218-5p-mediated repression of TXNDC5. |
| Confidence score: |
0.8148 |