| Expression pattern: |
UP |
| Associated gene: |
LTBP2 |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion, tumor growth and lung metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
CircWHSC1 functions as a ceRNA sponge for miR-532-3p to positively regulate LTBP2 expression, thereby augmenting malignant characteristics of cervical cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circWHSC1 was inversely associated with survival rate and might serve as an independent prognostic factor for CaCx patients. |
| Description: |
circWHSC1 is up-regulated in cervical cancer tissues and cell lines, and high circWHSC1 expression is associated with poorer patient survival. Functionally, circWHSC1 promotes cervical cancer proliferation, migration, invasion, tumor growth and lung metastasis while suppressing apoptosis. Mechanistically, circWHSC1 acts as a ceRNA for miR-532-3p to enhance LTBP2 expression, forming the circWHSC1/miR-532-3p/LTBP2 regulatory axis. |
| Confidence score: |
0.7795 |