| Expression pattern: |
UP |
| Associated gene: |
YAP1 / Yes-associated protein1 |
| Associated microRNA: |
miR-381-3p |
| Biological function: |
Promotes OSCC cell proliferation, invasion, migration and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ-HIPK3 functions as a miR-381-3p sponge to indirectly regulate YAP1 expression in OSCC. |
| Biological pathway or process: |
Hippo/YAP (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
Potential therapeutic strategy for OSCC. |
| Description: |
circ-HIPK3 is up-regulated in OSCC tissues and cell lines. It promotes OSCC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through a ceRNA mechanism in which circ-HIPK3 sponges miR-381-3p to increase YAP1 expression. The study suggests circ-HIPK3 as a potential therapeutic target for OSCC. |
| Confidence score: |
0.7177 |