| Expression pattern: |
UP |
| Associated gene: |
Snail1 |
| Associated microRNA: |
miR-378g |
| Biological function: |
CircSOD2 promotes ulcerative colitis progression by disrupting intestinal mucosal barrier function, reducing cell viability and tight junction-related protein expression, and increasing inflammatory cytokines and intestinal permeability; circSOD2 knockdown repairs intestinal mucosal barrier injury. |
| Molecular mechanism: |
CircSOD2 acts as a miRNA sponge for miR-378g and positively regulates Snail1 expression, thereby accelerating ulcerative colitis progression and intestinal mucosal barrier injury through the miR-378g/Snail1 pathway. |
| Biological pathway or process: |
ceRNA regulation (promotes); inflammation (promotes); apoptosis (other); EMT (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; ELISA; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
CircSOD2 is overexpressed in UC patients and higher in active UC than inactive UC, suggesting it may be a potential target for UC therapy. |
| Description: |
CircSOD2 is up-regulated in ulcerative colitis patients and in LPS-induced Caco2 UC models. It promotes intestinal mucosal barrier injury and inflammation by sponging miR-378g and positively regulating Snail1, while circSOD2 knockdown improves barrier function in vitro and in DSS-induced UC rats. The study suggests circSOD2 may be a therapeutic target for UC. |
| Confidence score: |
0.6536 |