circRNA basic information
circBase ID: hsa_circ_0032872
Name: hsa_circ_EML5
Synonym: circ_0032872
Host Gene: EML5
Genomic location(hg19): chr14:89172602-89210435:-
Genomic location(hg38): chr14:88706258-88744091:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic kidney disease / DKD
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cell culture supernatant exosomes
Cell lines:

HK-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: IL6
Associated microRNA: -
Biological function: Mitigates high glucose-induced inflammatory marker increase when overexpressed (reverses IL6 upregulation).
Molecular mechanism: Not specified; functional modulation assessed by plasmid overexpression affecting IL6 expression.
Biological pathway or process:

inflammation (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection
Clinical significance:

-
Description:

Exosomal circ_0032872 is down-regulated in exosomes from high glucose-stimulated HK-2 cells. Overexpression of circ_0032872 reverses high glucose-induced IL6 upregulation, suggesting an anti-inflammatory role relevant to DKD-associated tubular injury.
Confidence score:

0.3213
Other information
Title:

Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy
Published: 2023
PubMed ID: 38077483
Study type:

biological research
Data availability: GSE207495
Code availability: -