| Expression pattern: |
UP |
| Associated gene: |
INHBA |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
promotes gastric cancer cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0000654 sponges miR-149-5p to upregulate INHBA |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0000654 expression was related to tumor differentiation, TNM staging and lymph node metastasis |
| Description: |
circ_0000654 is up-regulated in gastric cancer and promotes malignant phenotypes and xenograft growth. Mechanistically, it functions as a miR-149-5p sponge to relieve repression of INHBA, thereby enhancing GC progression. |
| Confidence score: |
0.8005 |