| Expression pattern: |
UP |
| Associated gene: |
CREB1 |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
Promotes CRC cell proliferation, invasion, colony formation, and glycolysis; circ_002178 knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
circ_002178 acts as a ceRNA/molecular sponge for miR-542-3p, thereby up-regulating CREB1 expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Colony Formation Assay; ROC Analysis; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
circ_002178 is highly sensitive and reliable for CRC diagnosis. |
| Description: |
circ_002178 is up-regulated in colorectal cancer tissues and cell lines and may have diagnostic value based on ROC analysis. Functionally, it promotes CRC cell proliferation, invasion, colony formation, and glycolysis by acting as a ceRNA that sponges miR-542-3p and increases CREB1 expression. |
| Confidence score: |
0.8244 |