| Expression pattern: |
UP |
| Associated gene: |
HOXA10, Ago2 |
| Associated microRNA: |
miR-588 |
| Biological function: |
Promotes malignant progression (proliferation, invasion, migration) and radioresistance; inhibits apoptosis and radiosensitivity in NSCLC. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-588 to upregulate HOXA10, thereby promoting malignant phenotypes and radioresistance. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Colony Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0010235 might be a diagnostic indicator for NSCLC. |
| Description: |
circ_0010235 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, invasion, migration and radioresistance while inhibiting apoptosis and radiosensitivity. Mechanistically, it functions as a sponge for miR-588 to relieve repression of HOXA10, forming a circ_0010235/miR-588/HOXA10 axis. |
| Confidence score: |
0.8299 |