| Expression pattern: |
UP |
| Associated gene: |
NAP1L1, UBE2O |
| Associated microRNA: |
miR-217 |
| Biological function: |
promotes proliferation, migration, invasion and EMT in HCC cells; promotes angiogenesis in HUVECs via exosomal transfer; promotes regorafenib resistance |
| Molecular mechanism: |
ceRNA mechanism: circDCAF8 sponges miR-217 to upregulate NAP1L1; exosome-mediated transfer of circDCAF8 promotes angiogenesis and transmits regorafenib resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); angiogenesis (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; IF (Immunofluorescence); Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Tube Formation Assay; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining |
| Clinical significance: |
CircDCAF8 is upregulated in HCC tissues and cell lines, and is linked to an unfavourable prognosis for HCC patients. |
| Description: |
CircDCAF8 (hsa_circ_0014879), derived from the DCAF8 gene, is upregulated in HCC and promotes tumor proliferation, migration, invasion and EMT. It functions as a ceRNA by sponging miR-217 to increase NAP1L1, and it can be transferred via exosomes to enhance angiogenesis and to transmit regorafenib resistance. |
| Confidence score: |
0.8462 |