| Expression pattern: |
UP |
| Associated gene: |
TRIM65 |
| Associated microRNA: |
miR-379-5p |
| Biological function: |
circ_0011292 promotes NSCLC tumor progression, proliferation, migration, invasion, EMT and paclitaxel resistance, while inhibiting apoptosis and paclitaxel sensitivity. |
| Molecular mechanism: |
circ_0011292 functions as a ceRNA by sponging miR-379-5p, thereby upregulating TRIM65 and enhancing paclitaxel resistance in NSCLC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_0011292 was suggested as a promising therapeutic target and biomarker for overcoming chemotherapy resistance in NSCLC. |
| Description: |
circ_0011292 is upregulated in NSCLC tissues and paclitaxel-resistant NSCLC cells. Functional experiments show that circ_0011292 promotes malignant progression and paclitaxel resistance by sponging miR-379-5p and increasing TRIM65 expression, making it a potential therapeutic target for NSCLC chemotherapy resistance. |
| Confidence score: |
0.7591 |