circRNA basic information
circBase ID: hsa_circ_0052112
Name: hsa_circ_ZNF83
Synonym: -
Host Gene: ZNF83
Genomic location(hg19): chr19:53158813-53164096:-
Genomic location(hg38): chr19:52655560-52660843:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; normal adjacent tissue; blood plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AGO2, EIF4A3, PTB, MAPK1, STAT1, TRAF6, ERRB4
Associated microRNA: hsa-miR-142-5p, hsa-miR-146b-3p, hsa-miR-194, hsa-miR-324-5p, hsa-miR-515-5p, hsa-miR-568, hsa-miR-924
Biological function: potentially associated with disease progression/tumor aggressiveness and metastasis; may influence tumor behavior and response to hormonal therapies
Molecular mechanism: bioinformatically predicted miRNA sponge/ceRNA network involving miR-194 and hub genes; RBP binding predicted (AGO2, EIF4A3, PTB); hub genes enriched in PI3K/AKT-related processes
Biological pathway or process:

PI3K/AKT (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for breast cancer; elevated in tumor tissues and plasma, particularly in advanced stages and with lymph node involvement; proposed for diagnosis/prognosis and monitoring
Description:

hsa_circ_0052112 is up-regulated in breast cancer tumor tissue and plasma and is associated with advanced stage and lymph node involvement, supporting its potential as a diagnostic/prognostic biomarker. In silico analyses suggest it may act through a ceRNA network involving miR-194 and hub genes (MAPK1, STAT1, TRAF6, ERRB4) with enrichment in PI3K/AKT-related processes, and it is predicted to bind RBPs such as AGO2, EIF4A3 and PTB.
Confidence score:

0.348
Other information
Title:

Exploring the Role of hsa_circ_0052112 as a Potential Biomarker in Breast Cancer: Insights from Experimental and In Silico Analyses.

Journal: Avicenna journal of medical biotechnology
Published: 2025
PubMed ID: 40453910
Study type:

combined biological and clinical study
Data availability: -
Code availability: -