| Expression pattern: |
DN |
| Associated gene: |
LYVE1, Ago2 |
| Associated microRNA: |
miR-492 |
| Biological function: |
Inhibits HCC cell proliferation, migration, and invasion and delays in vivo tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-492, relieving miR-492-mediated repression of LYVE1. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0129047 is down-regulated in hepatocellular carcinoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits HCC proliferation, migration, invasion, and xenograft growth by sponging miR-492 to de-repress LYVE1 (circ_0129047/miR-492/LYVE1 axis). |
| Confidence score: |
0.7795 |