| Expression pattern: |
UP |
| Associated gene: |
AKNAD1, TRAb |
| Associated microRNA: |
hsa-miR-3151-5p, hsa-miR-1227-5p, hsa-miR-194-3p, hsa-miR-1296-3p, hsa-miR-3688-3p, hsa-miR-7112-3p, hsa-miR-8063, hsa-miR-4512, hsa-miR-7848-3p |
| Biological function: |
associated with immune system activation in Graves' disease (bioinformatically predicted). |
| Molecular mechanism: |
ceRNA network prediction (circRNA/miRNA/mRNA interaction network) for hsa_circRNA_000102. |
| Biological pathway or process: |
immune regulation (other); inflammation (other); STING/IFN (other); viral replication (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
hsa_circRNA_000102 expression levels in plasma exosomes correlate significantly with TRAb levels. |
| Description: |
hsa_circRNA_000102 is up-regulated in plasma exosomes from Graves' disease patients and was validated by RT-qPCR. Bioinformatics-based circRNA/miRNA/mRNA network and GO/KEGG analyses suggest it may participate in immune activation processes, including virus infection-related pathways and interferon-beta signaling. |
| Confidence score: |
0.5135 |