| Expression pattern: |
UP |
| Associated gene: |
TM9SF4 |
| Associated microRNA: |
miR-1248 |
| Biological function: |
promotes protective autophagy, anoikis-resistance, invasion and metastasis in prostate cancer cells |
| Molecular mechanism: |
ceRNA sponging miR-1248 to upregulate TM9SF4, leading to mTOR phosphorylation inhibition and autophagy activation |
| Biological pathway or process: |
autophagy (promotes); PI3K/AKT/mTOR (inhibits); metastasis (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; CCK8; Western Blot; IF (Immunofluorescence); TEM; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circ_0004585 can possibly be used for the PCa diagnosis and prognosis evaluation. |
| Description: |
circ_0004585 (circCEMIP; hsa_circ_0004585), derived from the CEMIP gene, is upregulated in prostate cancer tissues and anoikis-resistant PCa cells and mainly localizes to the cytoplasm. It promotes invasion/metastasis and anoikis-resistance by acting as a ceRNA that sponges miR-1248 to increase TM9SF4, which suppresses mTOR phosphorylation and enhances protective autophagy. |
| Confidence score: |
0.8007 |