| Expression pattern: |
UP |
| Associated gene: |
ACACA, AGO2 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes proliferation, migration, and invasion; promotes lipid metabolism reprogramming |
| Molecular mechanism: |
ceRNA mechanism: circKIF18B_003 sponges miR-370-3p to increase ACACA expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); lipid metabolism (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); circRIP; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circKIF18B_003 expression corresponded with shorter biochemical recurrence and showed strong predictive potential (ROC AUC = 0.780). |
| Description: |
circKIF18B_003 is up-regulated in prostate cancer and mainly localizes in the cytoplasm. It promotes PCa cell proliferation, migration, invasion, and lipid metabolic reprogramming by sponging miR-370-3p to upregulate ACACA, and its high expression is associated with worse biochemical recurrence outcome. |
| Confidence score: |
0.8912 |